Thanks Paul for writing this article. I just wish one could have the confidence in believing that people are able to consume real information instead of facile marketing blurbs. The human brain’s desire for simplicity means we’ll always fall for simple pitches. It may also be worth mentioning that at the heart of anti-oxidant compounds is the Haber-Weiss reaction, which can run in either direction depending on concentration. In other words, a massive amount of anti-oxidant could (in theory) suppress oxidative damage but just a fraction too little would actually accelerate the damage. And as a human would have to consume many kilograms of anti-oxidant to reach the doses used by researchers on c elegans, the best a supplement can do is merely make matters worse. Furthermore, the presence of free radicals can trigger mitochondrial apoptosis, leading to replacement of worn-out mitochondria by new, healthy ones. So suppressing the signals of oxidative damage is a huge mistake, even if it would be possible to do so.

All in all, let’s hope your article gets widespread attention so that 30 years from now the anti-oxidant fad will have gone the way of the fad for drinking one’s own urine in order to promote longevity.

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